If you get the message"Connection to Saffire/Saffire LE/Saffire Pro lost...." please check the firewire cable is seated properly in both Saffire and computer.
Saffire PRO only: Check that the Unit ID is set to the correct Saffire pro and hit the ID button
Try an alternative firewire port if available.
If there are any other firewire devices attached to the computer or Saffire then check for any driver / firmware
updates for the said device.